Intra-specific variability of feverfew: Correlations between parthenolide, morphological traits and seed origin

A. R. Cutlan, L. E. Bonilla, J. E. Simon, J. E. Erwin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Parthenolide, a biologically active sesquiterpene lactone found in feverfew [Tanacetum parthenium (L.) Schultz Bip., Asteraceae], has been indirectly linked to the anti-migraine action of feverfew preparations. Commercial preparations of feverfew leaves are known to vary widely in parthenolide content. Thirty-one feverfew accessions of diverse origin were examined for morphological traits and parthenolide content. Significant variation in parthenolide content was found among the populations. Mean parthenolide levels ranged from non-detectable to 1.68% ± 0.97 (per dry weight) based upon HPLC-UV-MS. In general, feverfew plants grown from wild-collected seed from botanical gardens and the USDA accessions had higher mean parthenolide levels (0.72% ± 0.57) than plants from commercial sources, including the generic material (0.34% ± 0.23) and cultivars (0.35% ± 0.40). Feverfew varieties with a light green/yellow leaf color had significantly higher mean parthenolide levels (1.61% ± 0.61%) than darker-leafed varieties. A significant positive correlation between days to anthesis and parthenolide content was observed. Parthenolide levels did not correlate with floral morphology. This study shows that further selection for improved horticultural attributes and natural product content has potential to improve feverfew for the botanical/medicinal plant industry.

Original languageEnglish (US)
Pages (from-to)612-617
Number of pages6
JournalPlanta Medica
Volume66
Issue number7
DOIs
StatePublished - Nov 20 2000

Keywords

  • Asteraceae
  • Bioactive plant products
  • Feverfew
  • Morphology
  • Parthenolide
  • Sesquiterpene lactone
  • Tanacetum parthenium

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