Abstract
A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantitities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.
Original language | English (US) |
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Pages (from-to) | 313-316 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 67 |
Issue number | 2-3 |
DOIs | |
State | Published - 1980 |
Keywords
- Analgesia
- Intrathecal
- Morphine
- Mouse
- Spinal cord