Intrathoracic pressure regulation during cardiopulmonary resuscitation: A feasibility case-series

Nicolas Segal, Brent Parquette, Jonathon Ziehr, Demetris Yannopoulos, David Lindstrom

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Aim of the study: Intrathoracic pressure regulation (IPR) is a novel, noninvasive therapy intended to increase cardiac output and blood pressure in hypotensive states by generating a negative end expiratory pressure of -12cm H2O between positive pressure ventilations. In this first feasibility case-series, we tested the hypothesis that IPR improves End tidal (ET) CO2 during cardiopulmonary resuscitation (CPR). ETCO2 was used as a surrogate measure for circulation. Methods: All patients were treated initially with manual CPR and an impedance threshold device (ITD). When IPR-trained medics arrived on scene the ITD was removed and an IPR device (CirQLATOR™) was attached to the patient's advanced airway (intervention group). The IPR device lowered airway pressures to -9mmHg after each positive pressure ventilation for the duration of the expiratory phase. ETCO2, was measured using a capnometer incorporated into the defibrillator system (LifePak™). Values are expressed as mean±SEM. Results were compared using paired and unpaired Student's t test. p values of <0.05 were considered statistically significant. Results: ETCO2 values in 11 patients in the case series were compared pre and during IPR therapy and also compared to 74 patients in the control group not treated with the new IPR device. ETCO2 values increased from an average of 21±1mmHg immediately before IPR application to an average value of 32±5mmHg and to a maximum value of 45±5mmHg during IPR treatment (p<0.001). In the control group ETCO2 values did not change significantly. Return of spontaneous circulation (ROSC) rates were 46% (34/74) with standard CPR and ITD versus 73% (8/11) with standard CPR and the IPR device (p<0.001). Conclusions: ETCO2 levels and ROSC rates were significantly higher in the study intervention group. These findings demonstrate that during CPR circulation may be significantly augmented by generation of a negative end expiratory pressure between each breath.

Original languageEnglish (US)
Pages (from-to)450-453
Number of pages4
Issue number4
StatePublished - Apr 2013


  • Cardiopulmonary resuscitation
  • Emergency medical services
  • Emergency medical technicians
  • Heart arrest/therapy
  • Humans
  • Respiratory mechanics


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