Intraventricular calcitonin gene-related peptide inhibits gastric acid secretion

J. J. Hughes; A. S. Levine; J. E. Morley; B. A. Gosnell; S. E. Silvis

doi:10.1016/0196-9781(84)90003-2

Intraventricular calcitonin gene-related peptide inhibits gastric acid secretion

J. J. Hughes, A. S. Levine, J. E. Morley, B. A. Gosnell, S. E. Silvis

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Abstract

Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide recently demonstrated to be a peptide expressed by the calcitonin gene in the rat central nervous system. Intracerebroventricular administration of CGRP in pylorus ligated rats resulted in a dose dependent suppression of gastric acid secretion. This effect was also present in acutely vagotomized rats. In addition, CGRP inhibited the stimulation of gastric acid secretion by thyrotropin releasing hormone. CGRP was considerably less potent in its effect on gastric acid than calcitonin, a well known central inhibitor of gastric acid secretion in the rat. This study suggests that CGRP may be a factor in the central regulation of gastric acid secretion in the rat.

Original language	English (US)
Pages (from-to)	665-667
Number of pages	3
Journal	Peptides
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0196-9781(84)90003-2
State	Published - 1984

Bibliographical note

Funding Information:
We thank Julie Kneip and Martha Grace for their expert technical assistance and JoAnn Tallman for her secretariala ssistance. This work was supported by the Veterans Administration research funds.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Calcitonin gene-related peptide
Gastric acid secretion

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title = "Intraventricular calcitonin gene-related peptide inhibits gastric acid secretion",

abstract = "Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide recently demonstrated to be a peptide expressed by the calcitonin gene in the rat central nervous system. Intracerebroventricular administration of CGRP in pylorus ligated rats resulted in a dose dependent suppression of gastric acid secretion. This effect was also present in acutely vagotomized rats. In addition, CGRP inhibited the stimulation of gastric acid secretion by thyrotropin releasing hormone. CGRP was considerably less potent in its effect on gastric acid than calcitonin, a well known central inhibitor of gastric acid secretion in the rat. This study suggests that CGRP may be a factor in the central regulation of gastric acid secretion in the rat.",

keywords = "Calcitonin gene-related peptide, Gastric acid secretion",

author = "Hughes, {J. J.} and Levine, {A. S.} and Morley, {J. E.} and Gosnell, {B. A.} and Silvis, {S. E.}",

note = "Funding Information: We thank Julie Kneip and Martha Grace for their expert technical assistance and JoAnn Tallman for her secretariala ssistance. This work was supported by the Veterans Administration research funds. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Hughes, J. J.

AU - Levine, A. S.

AU - Morley, J. E.

AU - Gosnell, B. A.

AU - Silvis, S. E.

N1 - Funding Information: We thank Julie Kneip and Martha Grace for their expert technical assistance and JoAnn Tallman for her secretariala ssistance. This work was supported by the Veterans Administration research funds. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1984

Y1 - 1984

N2 - Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide recently demonstrated to be a peptide expressed by the calcitonin gene in the rat central nervous system. Intracerebroventricular administration of CGRP in pylorus ligated rats resulted in a dose dependent suppression of gastric acid secretion. This effect was also present in acutely vagotomized rats. In addition, CGRP inhibited the stimulation of gastric acid secretion by thyrotropin releasing hormone. CGRP was considerably less potent in its effect on gastric acid than calcitonin, a well known central inhibitor of gastric acid secretion in the rat. This study suggests that CGRP may be a factor in the central regulation of gastric acid secretion in the rat.

AB - Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide recently demonstrated to be a peptide expressed by the calcitonin gene in the rat central nervous system. Intracerebroventricular administration of CGRP in pylorus ligated rats resulted in a dose dependent suppression of gastric acid secretion. This effect was also present in acutely vagotomized rats. In addition, CGRP inhibited the stimulation of gastric acid secretion by thyrotropin releasing hormone. CGRP was considerably less potent in its effect on gastric acid than calcitonin, a well known central inhibitor of gastric acid secretion in the rat. This study suggests that CGRP may be a factor in the central regulation of gastric acid secretion in the rat.

KW - Calcitonin gene-related peptide

KW - Gastric acid secretion

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Intraventricular calcitonin gene-related peptide inhibits gastric acid secretion

Abstract

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Keywords

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