Intraventricular calcitonin inhibits gastric acid secretion

John E. Morley, Allen S Levine, Stephen E. Silvis

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

Parenteral and intracerebroventricular administration of calcitonin in rats resulted in the suppression of gastric acid secretion. This suppression also occurred in rats with insulin-induced hypoglycemia and after the administration of thyrotropin-releasing hormone. Intracerebroventricularly administered calcitonin was 1000 times more effective than parenterally administered calcitonin in suppressing gastric acid secretion. Calcitonin also inhibited the development of stressinduced ulcers in rats.

Original languageEnglish (US)
Pages (from-to)671-673
Number of pages3
JournalScience
Volume214
Issue number4521
DOIs
StatePublished - Jan 1 1981

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