Abstract
CD8 + T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Here we used two-photon intravital microscopy to visualize the responses of CD8 + resident memory T cells (T RM cells) within the reproductive tracts of live female mice. We found that mucosal T RM cells were highly motile, but paused and underwent in situ division after local antigen challenge. T RM cell reactivation triggered the recruitment of recirculating memory T cells that underwent antigen-independent T RM cell differentiation in situ. However, the proliferation of pre-existing T RM cells dominated the local mucosal recall response and contributed most substantially to the boosted secondary T RM cell population. We observed similar results in skin. Thus, T RM cells can autonomously regulate the expansion of local immunosurveillance independently of central memory or proliferation in lymphoid tissue.
Original language | English (US) |
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Pages (from-to) | 173-182 |
Number of pages | 10 |
Journal | Nature immunology |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2018 |
Bibliographical note
Funding Information:This work was funded by the Howard Hughes Medical Institute Faculty Scholars program (D.M.) and the US National Institutes of Health (grants R01AI111671 and R01AI084913 to D.M.; grant R21AI123600 to B.J.B.). H.D.H. was funded by the Intramural Research Program of the US National Institute of Allergy and Infectious Diseases.
Funding Information:
We thank the members of the Masopust laboratory for helpful discussions. This work was funded by the Howard Hughes Medical Institute Faculty Scholars program (D.M.) and the US National Institutes of Health (grants R01AI111671 and R01AI084913 to D.M.; grant R21AI123600 to B.J.B.). H.D.H. was funded by the Intramural Research Program of the US National Institute of Allergy and Infectious Diseases.
Publisher Copyright:
© 2017 The Author(s).