Introduction to the membrane protein reviews: The interplay of structure, dynamics, and environment in membrane protein function

Jonathan N. Sachs, Donald M. Engelman

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

In our review, we introduce an organizational scheme for membrane protein function. It is the relationship between structure, dynamics, arid, environment that endows the membrane and its constituents with-remarkable sensitivity and robustness. Our understanding begins with landmark like those presented in the following chapters. Membrane proteins are notoriously difficult to study, and so, the work presented here on the ADP/ATP carrier [Nury et al. (2)], rhodopsin [Palczewski (24)], and the cytochrome b6f complex [Cramer et al. (35)] represents incredible progress in this now blossoming field.

Original languageEnglish (US)
Pages (from-to)707-712
Number of pages6
JournalAnnual Review of Biochemistry
Volume75
DOIs
StatePublished - 2006

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