Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India

Satagopan Uthra, Rajiv Raman, Bickol N. Mukesh, Kumari R. Padmaja, Pradeep G. Paul, Praveena Lakshmipathy, Perumal Gnanamoorthy, Tarun Sharma, Catherine A. McCarty, Govindasamy Kumaramanickavel

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29 Scopus citations

Abstract

A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalOphthalmic Genetics
Volume28
Issue number2
DOIs
StatePublished - Apr 2007

Bibliographical note

Funding Information:
We thank RD TATA Trust, Mumbai, India, for the financial grant and patients who participated in the study. We are very thankful to the Sankara Nethralaya Diabetic retinopathy project team for collecting the patients.

Keywords

  • Diabetic retinopathy
  • Hypoxia
  • Intronic VNTR
  • Type 2 diabetes
  • eNOS

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