Inversion of DNA charge by a positive polymer via fractionalization of the polymer charge

T. T. Nguyen, B. I. Shklovskii

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Charge inversion of a DNA double helix by an oppositely charged flexible polyelectrolyte (PE) is widely used for gene delivery. It is considered here taking into account the discreteness of the charges of DNA. We concentrate on the worst scenario case when in the neutral state of the DNA-PE complex, each of the DNA charges is locally compensated by a PE charge and show that charge inversion exists even in this case. When an additional PE molecule is adsorbed by DNA, its charge gets fractionalized into monomer charges of defects (tails and arches) on the background of the perfectly neutralized DNA. These charges spread all over the DNA eliminating the self-energy of PE. Fractionalization leads to a substantial charge inversion of DNA. We show that fractionalization mechanism of charge inversion works also for non-linear polymers such as dendrimers. Remarkably, such fractionalization happens for adsorption of both PE or dendrimers on a two-dimensional charged lattice as well. Relation of fractionalization to other mechanisms of charge inversion is discussed.

Original languageEnglish (US)
Pages (from-to)197-211
Number of pages15
JournalPhysica A: Statistical Mechanics and its Applications
Volume310
Issue number1-2
DOIs
StatePublished - Jul 1 2002

Bibliographical note

Funding Information:
We are grateful to A.V. Kabanov for the question which initiated this work, and A.Yu. Grosberg, V.A. Kabanov and P. Pincus for useful discussions of results. This work was supported by the NSF Grant No. DMR-9985785. T.T.N. is also supported by the Doctoral Dissertation Fellowship of the University of Minnesota.

Keywords

  • Charge inversion
  • DNA
  • Fractionalization

Fingerprint Dive into the research topics of 'Inversion of DNA charge by a positive polymer via fractionalization of the polymer charge'. Together they form a unique fingerprint.

Cite this