Investigating the function of deep cortical and subcortical structures using stereotactic electroencephalography: Lessons from the anterior cingulate cortex

Robert A. McGovern, Tarini Ratneswaren, Elliot H. Smith, Jennifer F. Russo, Amy C. Jongeling, Lisa M. Bateman, Catherine A. Schevon, Neil A. Feldstein, Guy M. McKhann, Sameer Sheth

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Stereotactic Electroencephalography (SEEG) is a technique used to localize seizure foci in patients with medically intractable epilepsy. This procedure involves the chronic placement of multiple depth electrodes into regions of the brain typically inaccessible via subdural grid electrode placement. SEEG thus provides a unique opportunity to investigate brain function. In this paper we demonstrate how SEEG can be used to investigate the role of the dorsal anterior cingulate cortex (dACC) in cognitive control. We include a description of the SEEG procedure, demonstrating the surgical placement of the electrodes. We describe the components and process required to record local field potential (LFP) data from consenting subjects while they are engaged in a behavioral task. In the example provided, subjects play a cognitive interference task, and we demonstrate how signals are recorded and analyzed from electrodes in the dorsal anterior cingulate cortex, an area intimately involved in decision-making. We conclude with further suggestions of ways in which this method can be used for investigating human cognitive processes.

Original languageEnglish (US)
Article numbere52773
JournalJournal of Visualized Experiments
Volume2015
Issue number98
DOIs
StatePublished - Apr 15 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Journal of Visualized Experiments.

Keywords

  • Anterior cingulate cortex
  • Electrode placement
  • Epilepsy
  • Issue 98
  • Local field potential
  • Neuroscience
  • Stereotactic electroencephalography

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