Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.
|Original language||English (US)|
|Number of pages||7|
|Journal||International Journal of Biological Macromolecules|
|State||Published - Mar 1 2019|
Bibliographical noteFunding Information:
This work was supported by Iran's National Talents Foundation , Nanotechnology Innovation Council (INIC), and Ministry of Science, Research and Technology . We thank Prof. Raj Suryanarayanan for use of TGA equipment, and Prof. Chun Wang and Mr. Samuel Hanson for help with cell culture experiments. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program.
Copyright 2019 Elsevier B.V., All rights reserved.
- Biological properties
- Cellulose nanocrystals
- Gelatin nanofibers