TY - JOUR
T1 - Investigation of morphological, mechanical and biological properties of cellulose nanocrystal reinforced electrospun gelatin nanofibers
AU - Hivechi, Ahmad
AU - Hajir Bahrami, S.
AU - Siegel, Ronald A
N1 - Publisher Copyright:
© 2018
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.
AB - Incorporation of nanoparticles into biomaterials is of interest due to the high demand for medical devices with enhanced mechanical properties. In this study, cellulose nanocrystals (CNC) were incorporated in electrospun gelatin nanofibers at various loadings (0–15% w/w) and characterized using XRD, TGA, TEM, SEM, FTIR, and tensile tests. Results obtained from TGA and tensile properties indicate that CNC were agglomerated at loadings exceeding 5%; however, TEM showed excellent dispersion of nanoparticles at 5% CNC. A slight increase in biodegradability of crosslinked gelatin nanofibers was observed with CNC incorporation. MTT cytotoxicity, fluorescent staining, and SEM images showed that CNC had no significant effect on cell growth and proliferation.
KW - Biological properties
KW - Cellulose nanocrystals
KW - Gelatin nanofibers
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U2 - 10.1016/j.ijbiomac.2018.11.214
DO - 10.1016/j.ijbiomac.2018.11.214
M3 - Article
C2 - 30476513
AN - SCOPUS:85057484779
SN - 0141-8130
VL - 124
SP - 411
EP - 417
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -