Investigation of paternal programming of breast cancer risk in female offspring in rodent models

Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, Thomas Prates Ong

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Emerging experimental evidence show that fathers’ experiences during preconception can influence their daughters’ risk of developing breast cancer. Here we describe detailed protocols for investigation in rats and mice of paternally mediated breast cancer risk programming effects.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages14
StatePublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

Bibliographical note

Funding Information:
C.C.F. was a recipient of a Ph.D. scholarship from the Brazilian National Council for Scientific and Technological Development (CNPq; Proc. 153478/2012-8). T.P.O. is the recipient of a researcher fellowship from CNPq (Proc. 307910/2016-4) and is supported by grants from CNPq (Proc. 448501/2014-7), the Food Research Center (FoRC), and the São Paulo State Research Funding Agency (Proc. 2013/07914-8). S.D.A. is supported by grants from the National Institutes of Health (K22CA178309-01A1) and the American Cancer Society (Research Scholar Grant).


  • 7,12-Dimethylbenz[a]anthracene
  • Breast cancer
  • Female offspring
  • Mammary gland development
  • Paternal programming
  • Preconceptional diet
  • Rodents

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