Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel

Xianju Zhou; Lihui Weng; Qiang Chen; Jianming Zhang; Deyan Shen; Zhuchuan Li; Manjun Shao; Jian Xu

doi:10.1002/pi.1207

Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel

Xianju Zhou, Lihui Weng, Qiang Chen, Jianming Zhang, Deyan Shen, Zhuchuan Li, Manjun Shao, Jian Xu

Radiology

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Abstract

It was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7°C, whereas it shifted to below O°C when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a 'sausage-like' or 'desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out.

Original language	English (US)
Pages (from-to)	1153-1157
Number of pages	5
Journal	Polymer International
Volume	52
Issue number	7
DOIs	https://doi.org/10.1002/pi.1207
State	Published - Jul 2003

Keywords

Hydrogel
PH sensitivity
Poly(acrylic acid-co-acrylamide)
Upper critical solution temperature

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title = "Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel",

abstract = "It was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7°C, whereas it shifted to below O°C when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a 'sausage-like' or 'desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out.",

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author = "Xianju Zhou and Lihui Weng and Qiang Chen and Jianming Zhang and Deyan Shen and Zhuchuan Li and Manjun Shao and Jian Xu",

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AU - Zhou, Xianju

AU - Weng, Lihui

AU - Chen, Qiang

AU - Zhang, Jianming

AU - Shen, Deyan

AU - Li, Zhuchuan

AU - Shao, Manjun

AU - Xu, Jian

PY - 2003/7

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N2 - It was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7°C, whereas it shifted to below O°C when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a 'sausage-like' or 'desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out.

AB - It was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7°C, whereas it shifted to below O°C when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a 'sausage-like' or 'desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out.

KW - Hydrogel

KW - PH sensitivity

KW - Poly(acrylic acid-co-acrylamide)

KW - Upper critical solution temperature

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Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel

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