Abstract
Dynorphin-(1-17) produces a highly specific increase in food ingestion. Similar enhancement of food ingestion is found with dynorphin fragments (1-10), (1-11), (1-13) and (3-13) but not with (1-8) and (1-9). Dynorphin B (rimorphin) also enhances food intake. The highly specific kappa agonist U-50,488 also enhances food intake as do a number of other kappa-opiate receptor agonists. These studies provided further support for the role of a highly specific dynorphin-kappa opioid receptor in the modulation of feeding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 797-800 |
| Number of pages | 4 |
| Journal | Peptides |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1983 |
Bibliographical note
Funding Information:We thank Martha Grace and Julie Kneip for excellent technical assistance. JoAnn Tallman provided secretarial assistance. This work was supported in part by the Veterans Administration.
Keywords
- Appetite
- Dynorphin
- Feeding
- Kappa receptor
- Opioids
- Rimorphin