Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in Streptomyces coelicolor M145

Andrew P. Marshall, Andrew R. Johnson, Marvin M. Vega, Regan J. Thomson, Erin E. Carlson

Research output: Contribution to journalArticlepeer-review


Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (2) as the natural product produced by Streptomyces coelicolor. Natural product 2 was initially assigned as butylcycloheptylprodigiosin (3), and only relatively recently was this assignment clarified. We present additional evidence of this assignment by comparing collisional cross sections (ω) of synthetic standards of 2, 3, and metacycloprodigiosin (4) to the cyclic prodiginine produced by S. coelicolor. Calculated theoretical ω values demonstrate that cyclic prodiginines could be identified without standards. This work highlights ion mobility as an efficient tool for the dereplication of natural products.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalJournal of Natural Products
Issue number1
StatePublished - Jan 24 2020

Bibliographical note

Funding Information:
This work was supported by an NSF CAREER Award (to E.E.C.), a Sloan Research Fellow Award (to E.E.C.), the National Institutes of Health (R01GM085322 and R01GM124089 to R.J.T.), and the University of Minnesota.

Funding Information:
Mass spectrometry analysis was performed, in part, at The University of Minnesota Department of Chemistry Mass Spectrometry Laboratory (MSL), supported by the Office of the Vice President of Research, College of Science and Engineering, and the Department of Chemistry at the University of Minnesota. The content of this paper is the sole responsibility of the authors and does not represent endorsement by the MSL.

Publisher Copyright:
© 2020 American Chemical Society and American Society of Pharmacognosy.

Copyright 2020 Elsevier B.V., All rights reserved.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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