Iron catalyzed C[sbnd]N bond formation

Sujit K. Ghorai, Vijaya G. Gopalsamuthiram, Anup M. Jawalekar, Rupesh E. Patre, Sitaram Pal

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Diversely functionalized nitrogen-containing heteroaromatic building blocks, fine chemicals and active pharmaceutical or agrochemical ingredients are conveniently prepared via C[sbnd]N bond formation as the key step. Since beginning of the last decade, there has been a flurry of intense research in forging C[sbnd]N bonds using iron catalysts due to their low cost, high natural abundance and non-toxic nature. The present review offers an overview of C[sbnd]N bond forming reactions involving aryl, allyl, propargyl and unactivated alkyl electrophilic substrates with nitrogen nucleophiles via the regular cross coupling reactions catalyzed by iron. In the miscellaneous section, a set of novel transformations facilitated by iron are included as well.

Original languageEnglish (US)
Pages (from-to)1769-1794
Number of pages26
JournalTetrahedron
Volume73
Issue number14
DOIs
StatePublished - Jan 1 2017

Keywords

  • Amidation
  • Amination
  • C-N bond
  • Cross-coupling
  • Iron catalysis
  • Iron copper co-catalysis
  • Sulfamidation

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