Focal therapies such as hyperthermia have been successfully used to treat solid localized tumors; however, they are not easily applied to cancers that may present in a disseminated form such as ovarian cancer. To address this need, iron oxide (IO) particles were incorporated into microporous poly(caprolactone) scaffolds previously shown to recruit disseminating cancer cells. Under an alternating magnetic field, IO-loaded scaffolds exhibited heating and killed ID8 ovarian cancer cells in vitro. After implantation in the intraperitoneal cavity of mice, IO-loaded scaffolds became infiltrated with tissue after 6–7 weeks, and infiltrated cells were successfully treated ex vivo. Finally, IO-loaded scaffolds noninvasively killed infiltrated cells in vivo as evidenced by decreases in number of nuclei. These studies demonstrate the promising use of IO-loaded scaffolds as a tool for noninvasive hyperthermia, which could be an innovative modality for treatment of disseminated cancers.
Bibliographical noteFunding Information:
National Institute of General Medical Sciences: NIHT32GM008347; University of Minnesota MRSEC, Grant/Award Number: DMR‐1420013; National Science Foundation, Grant/Award Number: DMR‐185204 Funding information
This work was supported by the Dr. Ralph and Marian Falk Medical Research Trust Bank of America, N.A., the Biotechnology Training Grant: NIHT32GM008347 (Tiffany Lam), the Kwanjeong Education Foundation (Hak Rae Lee), Boston Scientific Corporation (Qi Shao), the Kuhrmeyer Chair in Mechanical Engineering (John C. Bischof), the Research Experiences for Undergraduates (REU) Program of the National Science Foundation under Award Number DMR‐1852044 and through the University of Minnesota MRSEC under Award Number DMR‐1420013.
© 2020 American Institute of Chemical Engineers
- iron oxide