Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution

Daisuke Takahashi; Takehiko Yamanaka; Masaaki Sudo; David A. Andow

doi:10.1111/evo.13255

Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution

Daisuke Takahashi, Takehiko Yamanaka, Masaaki Sudo, David A. Andow

Entomology

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10 Scopus citations

Abstract

The evolution of resistance against pesticides is an important problem of modern agriculture. The high-dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We reformulate a two-patch model based on the Comins model and derive a simple quadratic approximation to analyze the effects of limited dispersal, refuge size, and dominance for high efficacy treatments on the rate of evolution. When a small but substantial number of heterozygotes can survive in the treated patch, a larger refuge always reduces the rate of resistance evolution. However, when dominance is small enough, the evolutionary dynamics in the refuge population, which is indirectly driven by migrants from the treated patch, mainly describes the resistance evolution in the landscape. In this case, for small refuges, increasing the refuge size will increase the rate of resistance evolution. Our analysis distils major driving forces from the model, and can provide a framework for understanding directional selection in source-sink environments.

Original language	English (US)
Pages (from-to)	1494-1503
Number of pages	10
Journal	Evolution
Volume	71
Issue number	6
DOIs	https://doi.org/10.1111/evo.13255
State	Published - Jun 2017

Bibliographical note

Funding Information:
D.T. carried out numerical and analytical investigations. T.Y., D.A.A, and D.T designed the study. D.T. and M.S. prepared an initial manuscript. All authors prepared the manuscript. We thank Dr. Yoshito Suzuki for helpful discussions. The work was supported by a grant from the Ministry of Agriculture, Forestry, and Fisheries of Japan (Genomics-based Technology for Agricultural Improvement, PRM-4201), a grant from the Kempe Foundation SMK-1447 to D.T., and USDA Regional research project NC-205 to D.A.A. We declare no competing financial or nonfinancial interests. The code is available in the Dryad data repository doi:https://doi.org/10.5061/dryad.mb4g0.

Publisher Copyright:
© 2017 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Keywords

Dominance
directional selection
genetically modified organism
high-dose/refuge strategy
pesticide resistance management
spatially implicit model

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution",

abstract = "The evolution of resistance against pesticides is an important problem of modern agriculture. The high-dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We reformulate a two-patch model based on the Comins model and derive a simple quadratic approximation to analyze the effects of limited dispersal, refuge size, and dominance for high efficacy treatments on the rate of evolution. When a small but substantial number of heterozygotes can survive in the treated patch, a larger refuge always reduces the rate of resistance evolution. However, when dominance is small enough, the evolutionary dynamics in the refuge population, which is indirectly driven by migrants from the treated patch, mainly describes the resistance evolution in the landscape. In this case, for small refuges, increasing the refuge size will increase the rate of resistance evolution. Our analysis distils major driving forces from the model, and can provide a framework for understanding directional selection in source-sink environments.",

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N2 - The evolution of resistance against pesticides is an important problem of modern agriculture. The high-dose/refuge strategy, which divides the landscape into treated and nontreated (refuge) patches, has proven effective at delaying resistance evolution. However, theoretical understanding is still incomplete, especially for combinations of limited dispersal and partially recessive resistance. We reformulate a two-patch model based on the Comins model and derive a simple quadratic approximation to analyze the effects of limited dispersal, refuge size, and dominance for high efficacy treatments on the rate of evolution. When a small but substantial number of heterozygotes can survive in the treated patch, a larger refuge always reduces the rate of resistance evolution. However, when dominance is small enough, the evolutionary dynamics in the refuge population, which is indirectly driven by migrants from the treated patch, mainly describes the resistance evolution in the landscape. In this case, for small refuges, increasing the refuge size will increase the rate of resistance evolution. Our analysis distils major driving forces from the model, and can provide a framework for understanding directional selection in source-sink environments.

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Is a larger refuge always better? Dispersal and dose in pesticide resistance evolution

Abstract

Bibliographical note

Keywords

UN SDGs

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