Is serum γ-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?

Ji Seun Lim, Jin Hoon Yang, Byung Yeol Chun, Shin Kam, David R. Jacobs, Duk Hee Lee

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

A series of studies in black and white women and men have suggested that serum γ-glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. If serum GGT is a marker of oxidative stress, it might have important implications both clinically and epidemiologically because measurement of serum GGT is easy, reliable, and not expensive. We examined the cross-sectional association between deciles of serum GGT and concentrations of serum antioxidants among 9083 adult participants in the third U.S. National Health and Nutrition Examination Survey. After adjustment for race, sex, age, and total cholesterol, serum concentration of GGT across all deciles was inversely associated with serum concentrations of α-carotene, β-carotene, β-cryptoxanthin, zeaxanthin/lutein, lycopene, and vitamin C (p for trend <.01, respectively). Vitamin E was not associated with serum GGT. All these associations were not materially different after additional adjustment for total energy intake, body mass index, smoking status, smoking amount, alcohol intake, and exercise. These associations were similarly observed among most subgroups. In conclusion, the current and previous studies strongly suggest that serum GGT level within its normal range may be an early marker of oxidative stress.

Original languageEnglish (US)
Pages (from-to)1018-1023
Number of pages6
JournalFree Radical Biology and Medicine
Volume37
Issue number7
DOIs
StatePublished - Oct 1 2004

Keywords

  • Biomarker
  • Free radicals
  • Oxidative stress
  • Serum antioxidants
  • γ-Glutamyltransferase

Fingerprint Dive into the research topics of 'Is serum γ-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?'. Together they form a unique fingerprint.

Cite this