Is there an association between bicuspid aortic valve and neuroblastoma?

Heather E Stefanski, Lauren Wedel, Courtney Haller, Mary Ella M Pierpont, Joanna L. Perkins

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


An association has been reported between neuroblastoma and congenital heart disease, frequently bicuspid aortic valve [Holzer and Franklin. Arch Dis Child 2002;87:61-64; George et al. J Pediatr 2004;144:444-448; Friedman et al. Pediatr Cardiol 1998; 19:480-481; Monte et al. Am J Pediatr Hematol Oncol 1985;7:109-116]. To evaluate this in a large patient group with neuroblastoma, we examined echocardiograms of patients with neuroblastoma from 1987 to January 2007 to determine if there was a higher incidence of bicuspid aortic valves compared to the general population without neuroblastoma. We found that only 0.7% of neuroblastoma patients had the congenital heart defect of bicuspid aortic valves compared with 1-2% in the general population [Braverman et al. Curr Prob Cardiol 2005;30:470-522]. Our data show that neuroblastoma is not associated with bicuspid aortic valves.

Original languageEnglish (US)
Pages (from-to)359-360
Number of pages2
JournalPediatric Blood and Cancer
Issue number2
StatePublished - Aug 2010


  • Bicuspid aortic valve
  • Neuroblastoma

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