TY - JOUR
T1 - Islet Amyloid, Islet-Amyloid Polypeptide, and Diabetes Mellitus
AU - Epstein, Franklin H.
AU - Johnson, Kenneth H.
AU - O'brien, Timothy D.
AU - Betsholtz, Christer
AU - Westermark, Per
PY - 1989/8/24
Y1 - 1989/8/24
N2 - A PREVIOUSLY undescribed protein, called insulinoma- or islet-amyloid polypeptide (IAPP), was recently identified as the principal constituent of amyloid deposits in a human insulin-producing tumor (insulinoma).1 This same protein was subsequently found to be the principal constituent of amyloid isolated from the pancreatic tissue of patients with Type II (non-insulin-dependent) diabetes mellitus and of adult cats with diabetes.2,3 Although these IAPP-derived amyloid deposits (Fig. 1) are the most characteristic morphologic abnormality of islets from patients with Type II diabetes mellitus4 5 6 7 and adult diabetic cats,8,9 the relation of islet amyloid to diabetes mellitus has often been discounted and remains controversial. This….
AB - A PREVIOUSLY undescribed protein, called insulinoma- or islet-amyloid polypeptide (IAPP), was recently identified as the principal constituent of amyloid deposits in a human insulin-producing tumor (insulinoma).1 This same protein was subsequently found to be the principal constituent of amyloid isolated from the pancreatic tissue of patients with Type II (non-insulin-dependent) diabetes mellitus and of adult cats with diabetes.2,3 Although these IAPP-derived amyloid deposits (Fig. 1) are the most characteristic morphologic abnormality of islets from patients with Type II diabetes mellitus4 5 6 7 and adult diabetic cats,8,9 the relation of islet amyloid to diabetes mellitus has often been discounted and remains controversial. This….
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U2 - 10.1056/NEJM198908243210806
DO - 10.1056/NEJM198908243210806
M3 - Review article
C2 - 2668761
AN - SCOPUS:0024342752
SN - 0028-4793
VL - 321
SP - 513
EP - 518
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 8
ER -
