TY - JOUR
T1 - Islet cell antibodies and histocompatibility antigens (HLA) in insulin-dependent diabetics and their first-degree relatives
AU - Barbosa, J.
AU - Chavers, B.
AU - Dunsworth, T.
AU - Michael, A.
PY - 1982
Y1 - 1982
N2 - We have studied HLA A, B, D, and DR and cytoplasmic islet cell antibodies (CICA) in 282 insulin-dependent diabetics (IDD) and 806 of their nondiabetic first-degree relatives. Fifty percent of the patients were positive in the first year of disease, but only 19% among those with disease for longer than 5 yr. No associations were found between CICA and HLA types, age at diagnosis, or family history. In the relatives of IDD patients CICA was present in 11/428 (2.6%) of the sibs of the probands, 18/311 (5.8%) of the parents, and 4/67 (6.0%) of the children.
AB - We have studied HLA A, B, D, and DR and cytoplasmic islet cell antibodies (CICA) in 282 insulin-dependent diabetics (IDD) and 806 of their nondiabetic first-degree relatives. Fifty percent of the patients were positive in the first year of disease, but only 19% among those with disease for longer than 5 yr. No associations were found between CICA and HLA types, age at diagnosis, or family history. In the relatives of IDD patients CICA was present in 11/428 (2.6%) of the sibs of the probands, 18/311 (5.8%) of the parents, and 4/67 (6.0%) of the children.
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U2 - 10.2337/diab.31.7.585
DO - 10.2337/diab.31.7.585
M3 - Article
C2 - 6761195
AN - SCOPUS:0019985666
SN - 0012-1797
VL - 31
SP - 585
EP - 588
JO - Diabetes
JF - Diabetes
IS - 7
ER -