Islet cell antibodies and histocompatibility antigens (HLA) in insulin-dependent diabetics and their first-degree relatives

J. Barbosa, B. Chavers, T. Dunsworth, A. Michael

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

We have studied HLA A, B, D, and DR and cytoplasmic islet cell antibodies (CICA) in 282 insulin-dependent diabetics (IDD) and 806 of their nondiabetic first-degree relatives. Fifty percent of the patients were positive in the first year of disease, but only 19% among those with disease for longer than 5 yr. No associations were found between CICA and HLA types, age at diagnosis, or family history. In the relatives of IDD patients CICA was present in 11/428 (2.6%) of the sibs of the probands, 18/311 (5.8%) of the parents, and 4/67 (6.0%) of the children.

Original languageEnglish (US)
Pages (from-to)585-588
Number of pages4
JournalDiabetes
Volume31
Issue number7
DOIs
StatePublished - 1982

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