Isolated optic nerve sarcoidosis

Sandip Suresh, Gregory S. Kosmorsky, Michael S. Lee

Research output: Contribution to journalArticlepeer-review


Objective: To report three cases of sarcoidosis confined to the optic nerve. Methods: Chart review of clinical, laboratory, imaging, and optic nerve biopsy findings and a review of the literature. Results: All three cases presented with progressive visual loss and showed enhancement of the intraorbital optic nerve on magnetic resonance imaging. There was no evidence for systemic disease, including a negative workup for sarcoidosis or other infiltrative pathologies. Optic nerve biopsy in each case showed non-caseating granulomas consistent with sarcoidosis. Conclusions: Sarcoidosis confined to the optic nerve is a rare phenomenon but should still be considered in the differential diagnosis of progressive optic neuropathy, even in the absence of systemic disease.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Issue number2
StatePublished - 2017

Bibliographical note

Funding Information:
Support: Unrestricted Grant from Research to Prevent Blindness (New York, NY) and the Lions Club of Minnesota (MSL). The funding organization had no role in the design or conduct of this research

Publisher Copyright:
© Mattioli 1885.


  • Optic Nerve
  • Optic Neuritis
  • Optic Neuropathy
  • Sarcoidosis

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