A 39 residue peptide from the tryptic digestion of bovine blood clotting factor X has been isolated by specific adsorption on barium citrate. The amino and carboxyl terminal sequences of the peptide were determined and compared to the vitamin K dependent Ca2+ binding region from bovine prothrombin. The factor X peptide was found to contain γ carboxyglutamic acid residues, and the results of independent analysis are consistent with all 14 glutamic acid residues as γ carboxyglutamic acid. The similarity of the factor X peptide to the prothrombin peptide supports the hypothesis that the vitamin K dependent blood clotting proteins are descended from a common ancestral gene.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - 1975|