Isolation and partial purification of lantana (Lantana camara L.) toxins

O. P. Sharma; R. K. Dawra; H. P.S. Makkar

doi:10.1016/0378-4274(87)90153-6

Isolation and partial purification of lantana (Lantana camara L.) toxins

O. P. Sharma, R. K. Dawra, H. P.S. Makkar

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Abstract

A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being lantadene A and lantadene B. Lantadene A was nontoxic in itself. Likewise, another fraction containing lantadene A, lantadene B and 3 more components with higher polarity was found to be non-toxic. The toxic component(s) are different from lantadene A/B but appear to resemble them very closely.

Original language	English (US)
Pages (from-to)	165-172
Number of pages	8
Journal	Toxicology Letters
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(87)90153-6
State	Published - Jul 1987
Externally published	Yes

Keywords

Lantana camara
guinea pigs
hepatotoxicity
lantadene A
lantadene B
lantana toxins

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AU - Makkar, H. P.S.

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AB - A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being lantadene A and lantadene B. Lantadene A was nontoxic in itself. Likewise, another fraction containing lantadene A, lantadene B and 3 more components with higher polarity was found to be non-toxic. The toxic component(s) are different from lantadene A/B but appear to resemble them very closely.

KW - Lantana camara

KW - guinea pigs

KW - hepatotoxicity

KW - lantadene A

KW - lantadene B

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Isolation and partial purification of lantana (Lantana camara L.) toxins

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