Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene Era

Robert A. Britton; Su Min Chen; Deeann Wallis; Thearith Koeuth; Bradford S. Powell; Lisa G. Shaffer; David Largaespada; Nancy A. Jenkins; Neal G. Copeland; Donald L. Court; James R. Lupski

doi:10.1006/geno.2000.6243

Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene Era

Robert A. Britton, Su Min Chen, Deeann Wallis, Thearith Koeuth, Bradford S. Powell, Lisa G. Shaffer, David Largaespada, Nancy A. Jenkins, Neal G. Copeland, Donald L. Court, James R. Lupski

Pediatrics - Hematology

Research output: Contribution to journal › Article › peer-review

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Abstract

Era is an essential GTPase that is required for proper cell cycle progression and cell division in Escherichia coli and is found in nearly all bacteria sequenced to date. To determine whether Era is also present in eukaryotic organisms, we searched the dbEST database and found EST clones coding for proteins that were similar to Era. Full sequencing of these ESTs from human and mouse identified a conserved homologue, ERAL1 (Era-like 1). ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome 11. ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	78-82
Number of pages	5
Journal	Genomics
Volume	67
Issue number	1
DOIs	https://doi.org/10.1006/geno.2000.6243
State	Published - Jul 1 2000

Bibliographical note

Funding Information:
We thank Debra Gilbert and Deborah Householder for excellent technical assistance. We also thank Catherine D. Kashork for the FISH mapping. This research was supported in part by the National Cancer Institute, DHHS.

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title = "Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene Era",

abstract = "Era is an essential GTPase that is required for proper cell cycle progression and cell division in Escherichia coli and is found in nearly all bacteria sequenced to date. To determine whether Era is also present in eukaryotic organisms, we searched the dbEST database and found EST clones coding for proteins that were similar to Era. Full sequencing of these ESTs from human and mouse identified a conserved homologue, ERAL1 (Era-like 1). ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome 11. ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer. (C) 2000 Academic Press.",

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AU - Britton, Robert A.

AU - Chen, Su Min

AU - Wallis, Deeann

AU - Koeuth, Thearith

AU - Powell, Bradford S.

AU - Shaffer, Lisa G.

AU - Largaespada, David

AU - Jenkins, Nancy A.

AU - Copeland, Neal G.

AU - Court, Donald L.

AU - Lupski, James R.

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AB - Era is an essential GTPase that is required for proper cell cycle progression and cell division in Escherichia coli and is found in nearly all bacteria sequenced to date. To determine whether Era is also present in eukaryotic organisms, we searched the dbEST database and found EST clones coding for proteins that were similar to Era. Full sequencing of these ESTs from human and mouse identified a conserved homologue, ERAL1 (Era-like 1). ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome 11. ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer. (C) 2000 Academic Press.

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Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene Era

Abstract

Bibliographical note

UN SDGs

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