Isolation of a trimer of α-tocopherol from mammalian liver

H. H. Draper; A. S. Csallany; Mei Chiu

doi:10.1007/BF02532000

Isolation of a trimer of α-tocopherol from mammalian liver

H. H. Draper, A. S. Csallany, Mei Chiu

Food Science and Nutrition

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Abstract

Evidence is presented for the formation in mammalian liver of a trimeric metabolite of α-tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of α-tocopherol with alkaline K₃Fe(CN)₆. In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl-p-quinone, are postulated to arise from reactions with lipid-free radicals or peroxides in the course of the antioxidant action of vitamin E.

Original language	English (US)
Pages (from-to)	47-54
Number of pages	8
Journal	Lipids
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/BF02532000
State	Published - Jan 1967

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abstract = "Evidence is presented for the formation in mammalian liver of a trimeric metabolite of α-tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of α-tocopherol with alkaline K3Fe(CN)6. In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl-p-quinone, are postulated to arise from reactions with lipid-free radicals or peroxides in the course of the antioxidant action of vitamin E.",

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AU - Csallany, A. S.

AU - Chiu, Mei

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AB - Evidence is presented for the formation in mammalian liver of a trimeric metabolite of α-tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of α-tocopherol with alkaline K3Fe(CN)6. In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl-p-quinone, are postulated to arise from reactions with lipid-free radicals or peroxides in the course of the antioxidant action of vitamin E.

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Isolation of a trimer of α-tocopherol from mammalian liver

Abstract

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