TY - CHAP
T1 - Isolectin IB4-mediated cytotoxic targeting of sensory neurons
AU - Vulchanova, Lucy
AU - Honda, Christopher N.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Lectins are carbohydrate-binding proteins that recognize distinct oligosaccharide moieties of glycoproteins and glycolipids. In vertebrates, endogenous lectins serve a variety of functions, including cell adhesion, cell recognition, signal transduction, and endocytosis, in both neuronal and nonneuronal cells (1-5). A role for cell surface carbohydrate recognition has been described in processes, such as fertilization, development, leukocyte homing, and the innate immune response (1,2). Among the known classes of vertebrate carbohydrate-binding proteins are some cytokines (e.g., interleukin 1β [IL-1β]) and growth factors, which possess a receptor-binding domain and a carbohydrate recognition domain (4,5).
AB - Lectins are carbohydrate-binding proteins that recognize distinct oligosaccharide moieties of glycoproteins and glycolipids. In vertebrates, endogenous lectins serve a variety of functions, including cell adhesion, cell recognition, signal transduction, and endocytosis, in both neuronal and nonneuronal cells (1-5). A role for cell surface carbohydrate recognition has been described in processes, such as fertilization, development, leukocyte homing, and the innate immune response (1,2). Among the known classes of vertebrate carbohydrate-binding proteins are some cytokines (e.g., interleukin 1β [IL-1β]) and growth factors, which possess a receptor-binding domain and a carbohydrate recognition domain (4,5).
UR - http://www.scopus.com/inward/record.url?scp=84890251113&partnerID=8YFLogxK
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U2 - 10.1007/978-1-59259-896-0_12
DO - 10.1007/978-1-59259-896-0_12
M3 - Chapter
AN - SCOPUS:84890251113
SN - 9781588291998
SP - 265
EP - 291
BT - Molecular Neurosurgery With Targeted Toxins
PB - Humana Press
ER -