Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the identification of new signaling targets for it have converged to indicate an unexpected function for this protein kinase: cell survival. Here, we summarize our emerging knowledge about how CK2 might participate in the transduction of survival signals.
Bibliographical noteFunding Information:
Research support was provided by grants from the INSERM, the CEA, the Association pour la Recherche sur le Cancer and the Fondation pour la Recherche Médicale (C.C.); and by United States Public Health Service Research Grant CA-15062, awarded by the National Cancer Institute, Dept of Health and Human Services, and by the Medical Research Fund of the United States Dept of Veterans Affairs and the Eagle Telethon fund (K.A.). We thank A. Davis, J. La Marre and R. Scaifes for stimulating discussions and critical readings of this manuscript. We regret that, owing to space limitation, we were unable to cite all the pertinent references.