TY - JOUR
T1 - KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion
AU - Myung, Kyungjae
AU - Braastad, Corey
AU - He, Dong Ming
AU - Hendrickson, Eric A.
PY - 1998/6/23
Y1 - 1998/6/23
N2 - The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.
AB - The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.
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U2 - 10.1073/pnas.95.13.7664
DO - 10.1073/pnas.95.13.7664
M3 - Article
C2 - 9636207
AN - SCOPUS:0032560473
SN - 0027-8424
VL - 95
SP - 7664
EP - 7669
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 13
ER -
