Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Carolien Koop-Nieuwelink, Sanaz Sedaghat, Unal Mutlu, Silvan Licher, Oscar H. Franco, M. Arfan Ikram, Mirjam I. Geerlings, M. Kamran Ikram, Daniel Bos

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.

Original languageEnglish (US)
Pages (from-to)821-826
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 2019
Externally publishedYes

Bibliographical note

Funding Information:
Sources of support: The Rotterdam Study is supported by the Erasmus MC; Erasmus University Rotterdam; Netherlands Organisation for Scientific Research (NWO); Netherlands Organisation for Health Research and Development (ZonMW); Research Institute for Diseases in the Elderly (RIDE); Netherlands Genomics Initiative; Ministry of Education, Culture and Science; Ministry of Health, Welfare and Sports; European Commission (DG XII); and Municipality of Rotterdam.

Publisher Copyright:
© 2019 - IOS Press and the authors. All rights reserved.

Copyright 2019 Elsevier B.V., All rights reserved.


  • Dementia
  • epidemiology
  • glomerular filtration rate
  • kidney function
  • stroke

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