Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Carolien Koop-Nieuwelink; Sanaz Sedaghat; Unal Mutlu; Silvan Licher; Oscar H. Franco; M. Arfan Ikram; Mirjam I. Geerlings; M. Kamran Ikram; Daniel Bos

doi:10.3233/JAD-181086

Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Carolien Koop-Nieuwelink, Sanaz Sedaghat, Unal Mutlu, Silvan Licher, Oscar H. Franco, M. Arfan Ikram, Mirjam I. Geerlings, M. Kamran Ikram, Daniel Bos

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.

Original language	English (US)
Pages (from-to)	821-826
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	67
Issue number	3
DOIs	https://doi.org/10.3233/JAD-181086
State	Published - 2019
Externally published	Yes

Bibliographical note

Funding Information:
The dedication, commitment, and contribution of inhabitants, general practitioners, and pharmacists of the Ommoord district to the Rotterdam Study are gratefully acknowledged. Sources of support: The Rotterdam Study is supported by the Erasmus MC; Erasmus University Rotterdam; Netherlands Organisation for Scientific Research (NWO); Netherlands Organisation for Health Research and Development (ZonMW); Research Institute for Diseases in the Elderly (RIDE); Netherlands Genomics Initiative; Ministry of Education, Culture and Science; Ministry of Health, Welfare and Sports; European Commission (DG XII); and Municipality of Rotterdam.

Funding Information:
Sources of support: The Rotterdam Study is supported by the Erasmus MC; Erasmus University Rotterdam; Netherlands Organisation for Scientific Research (NWO); Netherlands Organisation for Health Research and Development (ZonMW); Research Institute for Diseases in the Elderly (RIDE); Netherlands Genomics Initiative; Ministry of Education, Culture and Science; Ministry of Health, Welfare and Sports; European Commission (DG XII); and Municipality of Rotterdam.

Publisher Copyright:
© 2019 - IOS Press and the authors. All rights reserved.

Keywords

Dementia
epidemiology
glomerular filtration rate
kidney function
stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/JAD-181086

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abstract = "Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.",

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Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Abstract

Bibliographical note

Keywords

UN SDGs

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