Kidney regeneration and the role of stem cells

Scott Reule, Sandeep Gupta

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Given its complexity, high metabolic activity and excretory functions, the kidney is particularly susceptible to acute ischemic and toxin-mediated injury. Current therapies do not facilitate kidney regeneration, and there is an increasing interest in newer therapies that are based on cellular sources of kidney regeneration such as stem cell therapy. Our understanding of cellular sources of kidney regeneration and stem cells present in the adult kidney has dramatically evolved over the recent years. Herein, we have discussed the current understanding of kidney stem cells present in the adult mammalian kidney and their role in kidney regeneration. We have also summarized the best available evidence supporting the role of stem cells in kidney regeneration.

Original languageEnglish (US)
JournalOrganogenesis
Volume7
Issue number2
StatePublished - Jan 1 2011

Keywords

  • Kidney regeneration
  • Progenitor cells
  • Stem cells

Fingerprint Dive into the research topics of 'Kidney regeneration and the role of stem cells'. Together they form a unique fingerprint.

Cite this