Kinetic analysis of α-cyclodextrin interactions using polydiacetylene liposomes

John Brockgreitens, Snober Ahmed, Abdennour ABBAS

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

α-Cyclodextrin (α-CD) has specific interactions with a number of important molecules including neurotoxins, pesticides, and hydrophobic drugs. Here, we describe the kinetics of a competitive inhibition of the interaction of α-CD with chromogenic polydiacetylene (PDA) liposomes. The competitive inhibition of α-CD with chromogenic PDA liposomes has already been used for sensing and detection purposes. Here we show that this mechanism can be successfully applied to characterize the reaction kinetics of α-CD with optically inactive compounds such as paraoxon neurotoxins via simple colorimetric changes. This method would enable easy characterisation of the interactions of α-CD when used as a drug delivery system or for drug solubilisation.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume81
Issue number3-4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Colorimetric detection
  • Competitive assay
  • Cyclodextrin
  • Inclusion complex
  • Polydiacetylene liposome
  • Reaction kinetics

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