Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents

Joseph J. Topczewski, Daniel M. Quinn

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Although oxime nucleophiles can reactivate the AChE-phosphyl adduct, the adduct undergoes a reaction called aging. No compounds have been described that reactivate the aged-AChE adduct. A family of 2-methoxypyridinium species which reverse aging in a model system is presented. A kinetic study of this system, which includes an SAR analysis, demonstrates that the reaction is highly tunable based on the ring substituents.

Original languageEnglish (US)
Pages (from-to)1084-1087
Number of pages4
JournalOrganic Letters
Volume15
Issue number5
DOIs
StatePublished - Mar 2013

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