An enantioselective copper-catalyzed azide-alkyne cycloaddition (E-CuAAC) is reported by kinetic resolution. Chiral triazoles were isolated in high yield with limiting alkyne (up to 97:3 enantiomeric ratio (er)). A range of substrates were tolerated (>30 examples), and the reaction was scaled to >1 g. The er of a triazole product could be enhanced by recrystallization and the recovered scalemic azide could be racemized and recycled. Recycling the azide allows efficient use of the undesired azide enantiomer.
Bibliographical noteFunding Information:
This research was supported by the National Institute of General Medical Sciences of the National Institutes of Health, under Award No. R35GM124718. We also acknowledge NIH Shared Instrumentation Grant No. S10OD011952.
© 2019 American Chemical Society.