Abstract
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia that causes stroke affecting more than 2.3 million people in the US. Catheter ablation to terminate AF is successful for paroxysmal AF but suffers limitations with persistent AF patients as current mapping methods cannot identify AF active substrates outside of pulmonary vein region. In this work, we developed a novel Kurtosis based mapping technique that can accurately identify pivot points of the rotors that were induced in ex-vivo isolated rabbit heart. The results indicate that the chaotic nature of rotor pivot point results in higher Kurtosis compared to the periphery thereby enabling its accurate identification. Our results suggest that Kurtosis technique can be further applied to intra-atrial electrograms from AF patients with rotors to accurately identify the rotor pivot point by generating 3-dimensional (3D) patient-specific Kurtosis maps. Validation of this new Kurtosis based mapping technology is required through clinical studies with both paroxysmal and persistent AF patient data.
Original language | English (US) |
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Title of host publication | 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 497-500 |
Number of pages | 4 |
ISBN (Electronic) | 9781457702204 |
DOIs | |
State | Published - Oct 13 2016 |
Event | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: Aug 16 2016 → Aug 20 2016 |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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Volume | 2016-October |
ISSN (Print) | 1557-170X |
Other
Other | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 |
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Country/Territory | United States |
City | Orlando |
Period | 8/16/16 → 8/20/16 |
Bibliographical note
Publisher Copyright:© 2016 IEEE.