Labeling of calcitonin gene-related peptide and substance P increases in subnucleus caudalis of rabbit during maxillary sinusitis

A. K. Roche, Ioannis G. Koutlas, K. C. Kajander

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Abstract

Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) were evaluated in subnucleus caudalis following induction of sinusitis. Three days after induction, intensity of labeling for CGRP-LI and SP-LI increased in ipsilateral subnucleus caudalis. Labeling for CGRP-LI and SP-LI appeared normal at later time points (20 and 28 days). Early changes in these neuropeptides may contribute to the inflammatory process and painful symptoms accompanying sinusitis.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalBrain Research
Volume791
Issue number1-2
DOIs
StatePublished - Apr 27 1998

Bibliographical note

Funding Information:
We thank Dr. Robert Vickers for help with histopathology, and Jeffrey Zey and Angel Honda for excellent technical assistance. We also thank Dr. Jean Xu for help with evaluating the sections. We are grateful to Drs. Glenn Giesler and Don Simone for careful comments on an earlier version of this manuscript. This research was supported by grants from the National Institute for Dental Research (DE 10227) and from the National Institute for Neurological Diseases and Strokes (NS 29567 and NS 33908).

Keywords

  • Inflammation
  • Neuropeptide
  • Spinal
  • Trigeminal nucleus
  • Trigeminal nucleus

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