Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

Lili Liu; Chenguang Wang; Jiangnan Dun; Albert H.L. Chow; Changquan Calvin Sun

doi:10.1039/c8ce00787j

Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

Lili Liu, Chenguang Wang, Jiangnan Dun, Albert H.L. Chow, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.

Original language	English (US)
Pages (from-to)	5486-5489
Number of pages	4
Journal	CrystEngComm
Volume	20
Issue number	37
DOIs	https://doi.org/10.1039/c8ce00787j
State	Published - Jan 1 2018

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abstract = "Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.",

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AU - Wang, Chenguang

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AU - Sun, Changquan Calvin

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AB - Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.

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Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

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