Lack of dependence of mechanical properties of baicalein cocrystals on those of the constituent components

Lili Liu, Chenguang Wang, Jiangnan Dun, Albert H.L. Chow, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Commercial baicalein (α form) exhibits deficient tabletability. Cocrystals of baicalein with nicotinamide, caffeine, and isoniazid were all shown to display excellent tabletability, despite the three coformers having high, medium, and poor tabletability, respectively. A crystal structure analysis using the energy framework approach revealed that the superior tabletability of these cocrystals always correlated with structural features rendering high plasticity irrespective of the coformer involved.

Original languageEnglish (US)
Pages (from-to)5486-5489
Number of pages4
JournalCrystEngComm
Volume20
Issue number37
DOIs
StatePublished - Jan 1 2018

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