Lack of smooth muscle in the small pulmonary arteries of the native Ladakhi: Is the Himalayan highlander adapted?

M. L. Gupta, K. S. Rao, I. S. Anand, A. K. Banerjee, M. S. Boparai

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Chronic hypobaric hypoxia induces a mild degree of pulmonary arterial hypertension with structural alterations in the peripheral portions of the pulmonary arterial tree of the native Andean highlanders. On the other hand, animals indigenous to high attitude do not show these changes and are adapted to hypobaric hypoxia. The small pulmonary arteries of seven native Himalayan highlanders were examined at autopsy and found to be thin-walled with no medial hypertrophy of the muscular pulmonary arteries or muscularization of the arterioles. These findings suggest that the Himalayan highlanders may be adapted to hypobaric hypoxia.

Original languageEnglish (US)
Pages (from-to)1201-1204
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume145
Issue number5
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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