Large-scale sequence analysis of avian influenza isolates

John C. Obenauar, Jackie Denson, Perdeep K. Mehta, Xiaoping Su, Suraj Mukatira, David B. Finkelstein, Xiequn Xu, Jinhua Wang, Jing Ma, Yiping Fan, Karen M. Rakestraw, Robert Q. Webster, Erich Hoffmann, Scott Krauss, Jie Zheng, Ziwei Zhang, Clayton W. Naeve

Research output: Contribution to journalArticlepeer-review

457 Scopus citations

Abstract

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

Original languageEnglish (US)
Pages (from-to)1576-1580
Number of pages5
JournalScience
Volume311
Issue number5767
DOIs
StatePublished - Mar 17 2006

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