Large-scale sequence analysis of avian influenza isolates

John C. Obenauar; Jackie Denson; Perdeep K. Mehta; Xiaoping Su; Suraj Mukatira; David B. Finkelstein; Xiequn Xu; Jinhua Wang; Jing Ma; Yiping Fan; Karen M. Rakestraw; Robert Q. Webster; Erich Hoffmann; Scott Krauss; Jie Zheng; Ziwei Zhang; Clayton W. Naeve

doi:10.1126/science.1121586

Large-scale sequence analysis of avian influenza isolates

John C. Obenauar, Jackie Denson, Perdeep K. Mehta, Xiaoping Su, Suraj Mukatira, David B. Finkelstein, Xiequn Xu, Jinhua Wang, Jing Ma, Yiping Fan, Karen M. Rakestraw, Robert Q. Webster, Erich Hoffmann, Scott Krauss, Jie Zheng, Ziwei Zhang, Clayton W. Naeve

Institute for Health Informatics

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502 Scopus citations

Abstract

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

Original language	English (US)
Pages (from-to)	1576-1580
Number of pages	5
Journal	Science
Volume	311
Issue number	5767
DOIs	https://doi.org/10.1126/science.1121586
State	Published - Mar 17 2006

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title = "Large-scale sequence analysis of avian influenza isolates",

abstract = "The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.",

author = "Obenauar, {John C.} and Jackie Denson and Mehta, {Perdeep K.} and Xiaoping Su and Suraj Mukatira and Finkelstein, {David B.} and Xiequn Xu and Jinhua Wang and Jing Ma and Yiping Fan and Rakestraw, {Karen M.} and Webster, {Robert Q.} and Erich Hoffmann and Scott Krauss and Jie Zheng and Ziwei Zhang and Naeve, {Clayton W.}",

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AU - Obenauar, John C.

AU - Denson, Jackie

AU - Mehta, Perdeep K.

AU - Su, Xiaoping

AU - Mukatira, Suraj

AU - Finkelstein, David B.

AU - Xu, Xiequn

AU - Wang, Jinhua

AU - Ma, Jing

AU - Fan, Yiping

AU - Rakestraw, Karen M.

AU - Webster, Robert Q.

AU - Hoffmann, Erich

AU - Krauss, Scott

AU - Zheng, Jie

AU - Zhang, Ziwei

AU - Naeve, Clayton W.

PY - 2006/3/17

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Large-scale sequence analysis of avian influenza isolates

Abstract

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