Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.
Bibliographical noteFunding Information:
Acknowledgements This work was funded through NIH grants R01-AG024526 and P30-AG028740 to Dr. Carter and HL-051952 to Dr. Diz.
- ACE inhibitors
- Glucose tolerance
- Nitric oxide synthase (NOS) isoforms