Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti; Riccardo Calvani; Jameson DuPree; Hazel A. Lees; Silvia Giovannini; Dong Oh Seo; Thomas W. Buford; Kindal Sweet; Drake Morgan; Kevin Y.E. Strehler; Debra Diz; Stephen E. Borst; Natasha Moningka; Karina Krotova; Christy S. Carter

doi:10.1007/s11357-012-9428-4

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti, Riccardo Calvani, Jameson DuPree, Hazel A. Lees, Silvia Giovannini, Dong Oh Seo, Thomas W. Buford, Kindal Sweet, Drake Morgan, Kevin Y.E. Strehler, Debra Diz, Stephen E. Borst, Natasha Moningka, Karina Krotova, Christy S. Carter

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.

Original language	English (US)
Pages (from-to)	1061-1075
Number of pages	15
Journal	AGE
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/s11357-012-9428-4
State	Published - Aug 2013
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements This work was funded through NIH grants R01-AG024526 and P30-AG028740 to Dr. Carter and HL-051952 to Dr. Diz.

Keywords

ACE inhibitors
Aging
Glucose tolerance
Inflammation
L-NAME
MTOR
Mitochondria
Nitric oxide synthase (NOS) isoforms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1007/s11357-012-9428-4

OpenUrl availability

Full text

Cite this

Marzetti, E., Calvani, R., DuPree, J., Lees, H. A., Giovannini, S., Seo, D. O., Buford, T. W., Sweet, K., Morgan, D., Strehler, K. Y. E., Diz, D., Borst, S. E., Moningka, N., Krotova, K., & Carter, C. S. (2013). Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. AGE, 35(4), 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

Marzetti, E, Calvani, R, DuPree, J, Lees, HA, Giovannini, S, Seo, DO, Buford, TW, Sweet, K, Morgan, D, Strehler, KYE, Diz, D, Borst, SE, Moningka, N, Krotova, K & Carter, CS 2013, 'Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle', AGE, vol. 35, no. 4, pp. 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

@article{aa62abe6a30b48ca858ab316084837f6,

title = "Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle",

abstract = "Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.",

keywords = "ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms",

author = "Emanuele Marzetti and Riccardo Calvani and Jameson DuPree and Lees, {Hazel A.} and Silvia Giovannini and Seo, {Dong Oh} and Buford, {Thomas W.} and Kindal Sweet and Drake Morgan and Strehler, {Kevin Y.E.} and Debra Diz and Borst, {Stephen E.} and Natasha Moningka and Karina Krotova and Carter, {Christy S.}",

note = "Funding Information: Acknowledgements This work was funded through NIH grants R01-AG024526 and P30-AG028740 to Dr. Carter and HL-051952 to Dr. Diz.",

year = "2013",

month = aug,

doi = "10.1007/s11357-012-9428-4",

language = "English (US)",

volume = "35",

pages = "1061--1075",

journal = "AGE",

issn = "0161-9152",

publisher = "Springer International Publishing AG",

number = "4",

}

TY - JOUR

T1 - Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

AU - Marzetti, Emanuele

AU - Calvani, Riccardo

AU - DuPree, Jameson

AU - Lees, Hazel A.

AU - Giovannini, Silvia

AU - Seo, Dong Oh

AU - Buford, Thomas W.

AU - Sweet, Kindal

AU - Morgan, Drake

AU - Strehler, Kevin Y.E.

AU - Diz, Debra

AU - Borst, Stephen E.

AU - Moningka, Natasha

AU - Krotova, Karina

AU - Carter, Christy S.

N1 - Funding Information: Acknowledgements This work was funded through NIH grants R01-AG024526 and P30-AG028740 to Dr. Carter and HL-051952 to Dr. Diz.

PY - 2013/8

Y1 - 2013/8

N2 - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.

AB - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.

KW - ACE inhibitors

KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

KW - MTOR

KW - Mitochondria

KW - Nitric oxide synthase (NOS) isoforms

UR - http://www.scopus.com/inward/record.url?scp=84886950028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886950028&partnerID=8YFLogxK

U2 - 10.1007/s11357-012-9428-4

DO - 10.1007/s11357-012-9428-4

M3 - Article

C2 - 22639176

AN - SCOPUS:84886950028

SN - 0161-9152

VL - 35

SP - 1061

EP - 1075

JO - AGE

JF - AGE

IS - 4

ER -

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this