Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti, Riccardo Calvani, Jameson DuPree, Hazel A. Lees, Silvia Giovannini, Dong Oh Seo, Thomas W. Buford, Kindal Sweet, Drake Morgan, Kevin Y.E. Strehler, Debra Diz, Stephen E. Borst, Natasha Moningka, Karina Krotova, Christy S. Carter

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17 Scopus citations

Abstract

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling.

Original languageEnglish (US)
Pages (from-to)1061-1075
Number of pages15
JournalAGE
Volume35
Issue number4
DOIs
StatePublished - Aug 2013

Bibliographical note

Funding Information:
Acknowledgements This work was funded through NIH grants R01-AG024526 and P30-AG028740 to Dr. Carter and HL-051952 to Dr. Diz.

Keywords

  • ACE inhibitors
  • Aging
  • Glucose tolerance
  • Inflammation
  • L-NAME
  • MTOR
  • Mitochondria
  • Nitric oxide synthase (NOS) isoforms

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