Leaning to the left: Laterality in the zebrafish forebrain

Marnie E. Halpern, Jennifer O. Liang, Joshua T. Gamse

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

How the brain becomes lateralized is poorly understood. By contrast, much is known about molecular cues that specify the left-right axis of the body, fashioning the asymmetric morphology and positioning of the visceral organs. In zebrafish, the Nodal signaling pathway functions in visceral asymmetry and also in the embryonic brain, to bias laterality of the epithalamus. Formation of an asymmetric pineal complex differentially influences adjacent diencephalic nuclei, the left and right habenulae, which acquire distinctive molecular and cellular features. Results from the genetically tractable zebrafish system provide a promising entry point for exploring how left-right biases are established and propagated in the developing vertebrate brain.

Original languageEnglish (US)
Pages (from-to)308-313
Number of pages6
JournalTrends in Neurosciences
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2003

Bibliographical note

Funding Information:
We are grateful to Christine Thisse and Bernard Thisse for generously providing zebrafish brain markers and to Chris Wright and Luis Puelles for valuable discussions. Described research was supported in part by the NSF (M.E.H.) and by post-doctoral fellowships from NRSA (J.O.L.) and the American Cancer Society (J.T.G.).

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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