TY - JOUR
T1 - Learning to fish with genetics
T2 - A primer on the vertebrate model Danio rerio
AU - Holtzman, Nathalia G.
AU - Kathryn Iovine, M.
AU - Liang, Jennifer O.
AU - Morris, Jacqueline
N1 - Publisher Copyright:
© 2016 by the Genetics Society of America.
PY - 2016/7
Y1 - 2016/7
N2 - In the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology.
AB - In the last 30 years, the zebrafish has become a widely used model organism for research on vertebrate development and disease. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Research with this model has also expanded into other areas, including the genetic regulation of aging, regeneration, and animal behavior. Zebrafish are a popular model because of the ease with which they can be maintained, their small size and low cost, the ability to obtain hundreds of embryos on a daily basis, and the accessibility, translucency, and rapidity of early developmental stages. This primer describes the swift progress of genetic approaches in zebrafish and highlights recent advances that have led to new insights into vertebrate biology.
UR - http://www.scopus.com/inward/record.url?scp=84979898647&partnerID=8YFLogxK
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U2 - 10.1534/genetics.116.190843
DO - 10.1534/genetics.116.190843
M3 - Article
C2 - 27384027
AN - SCOPUS:84979898647
SN - 0016-6731
VL - 203
SP - 1069
EP - 1089
JO - Genetics
JF - Genetics
IS - 3
ER -