[Leu31,Pro34]Neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake

David C. Jewett, James Cleary, David W. Schaal, Travis Thompson, Allen S. Levine

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalBrain Research
Volume631
Issue number1
DOIs
StatePublished - Dec 17 1993

Keywords

  • Discriminative stimulus
  • Drug discrimination
  • Food intake
  • NPY 20-36
  • NPY receptor
  • Neuropeptide Y (NPY)
  • [Leu,Pro]NPY

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