Leveraging the cardio-protective and anticancer properties of resveratrol in cardio-oncology

Ibrahim Y. Abdelgawad, Marianne K.O. Grant, Beshay N. Zordoky

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Cardio-oncology is a clinical/scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of cancer treatments are known to cause cardiovascular toxicity, they are still widely used because they are highly effective. Unfortunately, therapeutic interventions to prevent and/or treat cancer treatment-induced cardiovascular toxicity have not been established yet. A major challenge for such interventions is to protect the cardiovascular system without compromising the therapeutic benefit of anticancer medications. Intriguingly, the polyphenolic natural compound resveratrol and its analogs have been shown in preclinical studies to protect against cancer treatment-induced cardiovascular toxicity. They have also been shown to possess significant anticancer properties on their own, and to enhance the anticancer effect of other cancer treatments. Thus, they hold significant promise to protect the cardiovascular system and fight the cancer at the same time. In this review, we will discuss the current knowledge regarding the cardio-protective and the anticancer properties of resveratrol and its analogs. Thereafter, we will discuss the challenges that face the clinical application of these agents. To conclude, we will highlight important gaps of knowledge and future research directions to accelerate the translation of these exciting preclinical findings to cancer patient care.

Original languageEnglish (US)
Article number627
JournalNutrients
Volume11
Issue number3
DOIs
StatePublished - Mar 2019

Bibliographical note

Funding Information:
B.N.Z. is a Masonic Cancer Center Women’s Health Scholar, sponsored by the Masonic Cancer Center, a comprehensive cancer center designated by the National Cancer Institute, and administered by the University of Minnesota Women’s Health Research Program. B.N.Z. is also supported by a research grant from the Rally Foundation for Childhood Cancer (Award ID 582420) and an institutional research grant from the American Cancer Society (Award #129819-IRG-16-189-58-IRG91).

Funding Information:
Funding: B.N.Z. is a Masonic Cancer Center Women’s Health Scholar, sponsored by the Masonic Cancer Center, a comprehensive cancer center designated by the National Cancer Institute, and administered by the University of Minnesota Women’s Health Research Program. B.N.Z. is also supported by a research grant from the Rally Foundation for Childhood Cancer (Award ID 582420) and an institutional research grant from the American Cancer Society (Award #129819-IRG-16-189-58-IRG91).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Anthracycline
  • Cancer
  • Cardio-oncology
  • Cardiotoxicity
  • Cardiovascular
  • Resveratrol

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