TY - JOUR
T1 - LFA-3, CD44, and CD45
T2 - Physiologic triggers of human monocyte TNF and IL-1 release
AU - Webb, Deborah S.A.
AU - Shimizu, Yoji
AU - Van Seventer, Gijs A.
AU - Shaw, Stephen
AU - Gerrard, Theresa L.
PY - 1990/9/14
Y1 - 1990/9/14
N2 - The monocyte-derived cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are central regulators of the immune response, but the physiologic stimuli for their release remain largely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-α and IL-1β release. In addition, TNF-α was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.
AB - The monocyte-derived cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are central regulators of the immune response, but the physiologic stimuli for their release remain largely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-α and IL-1β release. In addition, TNF-α was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.
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M3 - Article
C2 - 1697984
AN - SCOPUS:0025185580
SN - 0036-8075
VL - 249
SP - 1295
EP - 1297
JO - Science
JF - Science
IS - 4974
ER -