Introduction The impact of blood pressure on brain volumes may be time-dependent or pattern-dependent. Methods Of 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (∼24 or ∼15 years prior and concurrent with neuroimaging) with late life brain volumes. Results Higher diastolic blood pressure ∼24 years prior, higher systolic and pulse pressure ∼15 years prior, and consistently elevated or rising systolic blood pressure from ∼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension ∼15 years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus: −0.27 standard units, 95% CI: −0.51, −0.03). Discussion Hypertension 15 to 24 years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental.
Bibliographical noteFunding Information:
A.L.C.S., L.W., M.G., L.H.C., A.A., M.C.P., T.H.M., and R.F.G. report no conflicts of interest. Dr. C.R.J. Jr. serves on a scientific advisory board for Eli Lilly & Company and receives research support from the NIH / NIA ( R01-AG011378 , U01-HL096917 , U01-AG024904 , RO1 AG041851 , R01 AG37551 , R01AG043392 , U01-AG06786 ) and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation. D.K. serves as Deputy Editor for Neurology; serves on a Data Safety Monitoring Board for Lundbeck Pharmaceuticals and for the DIAN study; is an investigator in clinical trials sponsored by TauRX Pharmaceuticals, Lilly Pharmaceuticals and the Alzheimer's Disease Cooperative Study; and receives research support from the NIH.
Melinda C. Power is supported by the NIA ( T32 AG027668 ). The ARIC is carried out as a collaborative study supported by NHLBI contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). Neurocognitive data is collected by U01 HL096812, HL096814, HL096899, HL096902, HL096917 with previous brain MRI examinations funded by R01-HL70825. The sponsors had no role in the design and conduct of the study; collection management, analysis and interpretation of the data; or preparation review, or approval of the manuscript.
© 2016 The Alzheimer's Association
Copyright 2017 Elsevier B.V., All rights reserved.
- Alzheimer's disease
- Blood pressure
- Brain volumes
- Cohort study
- Magnetic resonance imaging