Limitations of All Empirical Single-Parameter Solvent Strength Scales in Reversed-Phase Liquid Chromatography

Won Jo Cheong; Peter W. Carr

doi:10.1021/ac00189a013

Limitations of All Empirical Single-Parameter Solvent Strength Scales in Reversed-Phase Liquid Chromatography

Won Jo Cheong, Peter W. Carr

Chemistry (Twin Cities)

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Abstract

The relationships between the solute capacity factor and Relchardt's E_τ or the Kamlet-Taft π* scale in hydroorganic mixtures have been studied for a series of alkylbenzenes. It has been shown that, for such simple nonpolar solutes, linearity in plots of in k' against a single solvent polarity parameter is observed only over a limited range in composition. At least two solvent parameters are needed In order to account for the cavity formation and solute-solvent Interaction processes that control retention in reversed-phase liquid chromatography.

Original language	English (US)
Pages (from-to)	1524-1529
Number of pages	6
Journal	Analytical Chemistry
Volume	61
Issue number	14
DOIs	https://doi.org/10.1021/ac00189a013
State	Published - Jul 1989

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abstract = "The relationships between the solute capacity factor and Relchardt's Eτ or the Kamlet-Taft π* scale in hydroorganic mixtures have been studied for a series of alkylbenzenes. It has been shown that, for such simple nonpolar solutes, linearity in plots of in k' against a single solvent polarity parameter is observed only over a limited range in composition. At least two solvent parameters are needed In order to account for the cavity formation and solute-solvent Interaction processes that control retention in reversed-phase liquid chromatography.",

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Limitations of All Empirical Single-Parameter Solvent Strength Scales in Reversed-Phase Liquid Chromatography

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