Limitations of All Empirical Single-Parameter Solvent Strength Scales in Reversed-Phase Liquid Chromatography

Won Jo Cheong, Peter W Carr

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

The relationships between the solute capacity factor and Relchardt's E τ or the Kamlet-Taft π* scale in hydroorganic mixtures have been studied for a series of alkylbenzenes. It has been shown that, for such simple nonpolar solutes, linearity in plots of in k' against a single solvent polarity parameter is observed only over a limited range in composition. At least two solvent parameters are needed In order to account for the cavity formation and solute-solvent Interaction processes that control retention in reversed-phase liquid chromatography.

Original languageEnglish (US)
Pages (from-to)1524-1529
Number of pages6
JournalAnalytical Chemistry
Volume61
Issue number14
DOIs
StatePublished - Jul 1989

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