Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

Katherine L. Cook; Jessica L. Schwartz-Roberts; William T. Baumann; Robert Clarke

doi:10.1080/23723556.2015.1023928

Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

Katherine L. Cook, Jessica L. Schwartz-Roberts, William T. Baumann, Robert Clarke

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

Original language	English (US)
Article number	e1023928
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1023928
State	Published - Jan 2 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, © 2016 Taylor & Francis Group, LLC.

Keywords

ATG7
IRF1 tumor suppressor
autophagy
breast cancer
estrogen receptor
unfolded protein response

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1080/23723556.2015.1023928

OpenUrl availability

Full text

Cite this

@article{8ca05f21409348b1b6bc3b60e430ab16,

title = "Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer",

abstract = "Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.",

keywords = "ATG7, IRF1 tumor suppressor, autophagy, breast cancer, estrogen receptor, unfolded protein response",

author = "Cook, {Katherine L.} and Schwartz-Roberts, {Jessica L.} and Baumann, {William T.} and Robert Clarke",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor & Francis Group, LLC.",

year = "2016",

month = jan,

day = "2",

doi = "10.1080/23723556.2015.1023928",

language = "English (US)",

volume = "3",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

AU - Cook, Katherine L.

AU - Schwartz-Roberts, Jessica L.

AU - Baumann, William T.

AU - Clarke, Robert

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

AB - Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

KW - ATG7

KW - IRF1 tumor suppressor

KW - autophagy

KW - breast cancer

KW - estrogen receptor

KW - unfolded protein response

UR - http://www.scopus.com/inward/record.url?scp=85048240486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048240486&partnerID=8YFLogxK

U2 - 10.1080/23723556.2015.1023928

DO - 10.1080/23723556.2015.1023928

M3 - Article

AN - SCOPUS:85048240486

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

M1 - e1023928

ER -

Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this