The rates of linoleic acid solubilization in aqueous solutions of sodium taurodeoxycholate were measured at 37°C using a spinning liquid disc. The liquid disc is made of a polymer film whose pores contain the liquid being solubilized. Measurements of heptanoic acid dissolution show that the liquid disc behaves like a solid disc of 10% smaller area. Measurements of linoleic acid solubilization show characteristics of diffusion and surface reaction in series. The surface reaction is apparently controlled by bile salt adsorption.
Bibliographical noteFunding Information:
The ideas of a rotating liquid disc were first sharply focused for us by Dr. W. J. Ward of the General Electric Company. The research was primarily supported by the National Institute of Arthritis, Metabolic and Digestive Diseases Grant No. SR01-AM16143. Other support came from the National Science Foundation Grants CPE80-17376 and CPE80-14567.